the position has high level acｃｏｕｎｔabilities that are critical to the ｄｅｌivery of clinical development objectives and portfolio value targets. in this position you will be providing leadership in the development of new medicines targeted at indications in the field of oncology. you will have significant responsibilities in planning, evaluating, budgeting and ｅｘｅｃuting all clinical activities for phase i to phase iii studies.

responsibilities:

develop training plans across clinical operations to enhance overall project ｅｘｅｃution and ｄｅｌivery capabilities
ensure operational processes, systems and standards are adopted and implemented consistently across trials
development of talent, including mentoring, coaching, and performance management within clinical operations
responsible for overall clinical operations strategy, tactical planning, and alignment with broader organizational goals
responsible for utilizing metrics to drive performance and productivity to ensure clinical studies meet overall goals
responsible for clinical trial sourcing and takes a lead role in vendor governance
provide input and guidance on feasibility for specific disease areas to enable timely and effective clinical trial ｅｘｅｃution
explore and seek innovative initiatives to continuously improve clinical trial ｅｘｅｃution
responsible for the ｓｅｌｅｃｔion of research sites, contract negotiation, and coordination of meetings associated with clinical trials

qualifications：
degree preferred in a science or healthcare discipline
you will possess significant industry experience gained from the cro, pharmaceutical or biotech industries (or related)
your background will be complemented with experience gained in working in cross-functional teams with successful product development and commercialization based on strong science, commercial insights, market research and competitive intelligence

岗位职责：
1.负责研发阶段药物先导分子的成药性评价，纯度和性质分析，设计和实施药物的成药性评价实验，包括单抗，双抗，融合蛋白等；
2.负责基于计算机、抗体序列及结构的成药性预测工作；
3.设计和实施生物大分子药物纯度，理化特性和稳定性的相关理化评价实验；
4.负责抗体药物的液相色谱等仪器分析，熟练掌握样品前处理、仪器操作、日常维护和数据处理工作。
任职要求：
1.分析化学、药物分析、生物化学等相关专业毕业，大分子药物分析工作经验；
2.掌握各种蛋白分析方法，包括：毛细管电泳（ce-sds, cief）、液相色谱hplc/uplc（sec，hic），具备质谱lc-ms及结构分析 （包括分子量测定，肽谱分析, 糖谱及二硫键分析）等实验技能；
3.熟悉抗体成药性评价的技术手段：psr, ac-sins, bvp, tm等
4.了解各种技术手段以评价蛋白质药物的稳定性，结合活性，粘性，粒径；
5.有蛋白相互作用spr（biacore）， bli检测经验优先

岗位职责：
1.构建抗体突变文库，执行抗体文库（酵母、噬菌体）的表面展示筛选，以支持抗体药研发项目。参与酵母展示平台优化及新方法的开发工作
2.完成细胞培养，elisa，流式细胞仪检测及流式细胞仪分选工作
3.基本分子生物学理论和设计，包括引物设计，质粒构建，pcr
4.在项目管理周期内按时完成任务，完整真实地记录实验数据及撰写实验报告
5.进行实验室规划和建设、团队组建、实验流程、仪器设备的操作和维护
任职要求：
1.药学、药理学、生物化学、分子生物学、细胞生物学、免疫学、生物技术等生物相关专业硕士及以上学历；至少2年以上药企或实验室工作经验；
2.熟练掌握表面展示、建库和筛选的流程，有成功的项目经验优先，有酵母展示经验优先；
3.工作认真细致，责任心强，具有良好的职业素养；